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Nicoletta Zoppi Selected Research

Ehlers-Danlos Syndrome (Syndrome, Ehlers-Danlos)

11/2021Matrix Metalloproteinases Inhibition by Doxycycline Rescues Extracellular Matrix Organization and Partly Reverts Myofibroblast Differentiation in Hypermobile Ehlers-Danlos Syndrome Dermal Fibroblasts: A Potential Therapeutic Target?
1/2021Biological insights in the pathogenesis of hypermobile Ehlers-Danlos syndrome from proteome profiling of patients' dermal myofibroblasts.
1/2019Molecular insights in the pathogenesis of classical Ehlers-Danlos syndrome from transcriptome-wide expression profiling of patients' skin fibroblasts.
4/2018Dermal fibroblast-to-myofibroblast transition sustained by αvß3 integrin-ILK-Snail1/Slug signaling is a common feature for hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders.
10/2012Type III and V collagens modulate the expression and assembly of EDA(+) fibronectin in the extracellular matrix of defective Ehlers-Danlos syndrome fibroblasts.
2/2012Mutations in FKBP14 cause a variant of Ehlers-Danlos syndrome with progressive kyphoscoliosis, myopathy, and hearing loss.
8/2008Rescue of migratory defects of Ehlers-Danlos syndrome fibroblasts in vitro by type V collagen but not insulin-like binding protein-1.
6/2008FAK-independent alphavbeta3 integrin-EGFR complexes rescue from anoikis matrix-defective fibroblasts.
4/2004Exclusion of candidate genes in a family with arterial tortuosity syndrome.
4/2004Human fibroblasts with mutations in COL5A1 and COL3A1 genes do not organize collagens and fibronectin in the extracellular matrix, down-regulate alpha2beta1 integrin, and recruit alphavbeta3 Instead of alpha5beta1 integrin.

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Nicoletta Zoppi Research Topics

Disease

10Ehlers-Danlos Syndrome (Syndrome, Ehlers-Danlos)
11/2021 - 04/2004
2Loeys-Dietz Syndrome
11/2019 - 04/2006
2Wounds and Injuries (Trauma)
01/2019 - 10/2008
2Type IV Ehlers-Danlos Syndrome
01/2018 - 10/2012
2Joint Instability (Joint Laxity)
02/2012 - 04/2004
2Neoplasms (Cancer)
06/2007 - 04/2003
1Osteogenesis Imperfecta (Lobstein Disease)
01/2020
1Chronic Mucocutaneous Candidiasis
11/2019
1Cicatrix (Scar)
10/2019
1Inflammation (Inflammations)
03/2018
1Rupture
01/2018
1Spondyloepimetaphyseal Dysplasia With Joint Laxity
03/2015
1Pathologic Processes
10/2012
1Muscle Hypotonia (Hypotonia)
02/2012
1Hearing Loss (Hearing Impairment)
02/2012
1Muscular Diseases (Myopathy)
02/2012
1Scoliosis
02/2012
1Neuroblastoma
06/2007
1Hepatocellular Carcinoma (Hepatoma)
06/2007
1Carcinoma (Carcinomatosis)
06/2007
1Type 2 Diabetes Mellitus (MODY)
04/2006
1Aortic Aneurysm (Aneurysm, Aortic)
04/2006
1Hernia (Hernias)
04/2004
1Neoplasm Metastasis (Metastasis)
04/2003

Drug/Important Bio-Agent (IBA)

7Fibronectins (Fibronectin)IBA
01/2019 - 04/2003
5IntegrinsIBA
01/2019 - 04/2004
3Collagen Type V (Type V Collagen)IBA
01/2019 - 08/2008
3Proteins (Proteins, Gene)FDA Link
01/2019 - 04/2003
3CollagenIBA
01/2018 - 04/2004
2Collagen Type III (Type III Collagen)IBA
01/2018 - 10/2012
1Doxycycline (Periostat)FDA LinkGeneric
11/2021
1Matrix Metalloproteinases (MMPs)IBA
11/2021
1Biological ProductsIBA
01/2021
1ProteomeIBA
01/2021
1alpha2 Subunit Collagen Type IIBA
01/2020
1beta-cyclodextrin tetradecasulfate (CTDS)IBA
11/2019
1Transforming Growth Factor-beta Type II ReceptorIBA
11/2019
1tenascin XIBA
10/2019
1Glycine (Aminoacetic Acid)FDA LinkGeneric
01/2018
1GlycosaminoglycansIBA
03/2015
1Proteoglycans (Proteoglycan)IBA
03/2015
1galactosylxylosylprotein 3-beta-galactosyltransferaseIBA
03/2015
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
10/2012
1pyridinolineIBA
02/2012
1Insulin (Novolin)FDA Link
08/2008
1Integrin alphaVbeta3IBA
06/2008
1Amino AcidsFDA Link
06/2007
1Peptides (Polypeptides)IBA
06/2007
13-hydroxy-5-estrane-17-carbonitrile (ACN)IBA
06/2007
1Transforming Growth Factor beta (TGF-beta)IBA
04/2006
1Facilitative Glucose Transport Proteins (Glucose Transporter)IBA
04/2006